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Laying New Tracks: Psychedelics Unlock Neuroplasticy & Enable Working Internal Working Model Updates

Laying New Tracks In The Snow - Psychedelic Therapy For Anxiety, Depression, and PTSD


In recent years, there has been a growing interest in the potential therapeutic benefits of psychedelic medicines, including ketamine. Beyond their well-known mind-altering effects, these substances have been found to have a profound impact on neuroplasticity, the brain's remarkable ability to rewire and adapt itself. This phenomenon holds the key to understanding how psychedelic medicines enable the updating of our "internal working models," shaping our perceptions, behaviors, and emotional responses.

Neuroplasticity and Internal Working Models

Neuroplasticity, often referred to as the brain's "plastic" nature, refers to its ability to reorganize itself by forming new neural connections and pathways throughout life. These changes can occur in response to learning, experience, and environmental factors. Our "internal working models" are cognitive frameworks that help us interpret and navigate the world. They are the mental blueprints that shape our thoughts, emotions, and behaviors.

The Role of Psychedelic Medicines

Recent research suggests that psychedelic medicines, such as ketamine, can facilitate neuroplasticity by altering the brain's neural circuitry. Ketamine, in particular, acts on the glutamate system, a neurotransmitter that plays a crucial role in synaptic plasticity—the process by which neurons strengthen or weaken their connections. By temporarily altering neural pathways, ketamine creates a unique window of opportunity for the brain to revise outdated internal working models.

Updating Internal Working Models

When individuals undergo psychedelic experiences, their minds often transcend conventional thought patterns, enabling them to view their internal working models from a fresh perspective. This altered state of consciousness allows individuals to revisit traumatic memories, confront suppressed emotions, and reevaluate entrenched beliefs. As a result, the brain forms new connections, dismantling old frameworks and paving the way for updated internal working models that are more adaptive and aligned with current reality.

Therapeutic Applications

The capacity of psychedelic medicines to enhance neuroplasticity and update internal working models has significant implications for mental health treatment. Clinical trials have demonstrated promising results in using ketamine-assisted therapy to treat conditions such as depression, anxiety, and post-traumatic stress disorder. By facilitating the rewiring of neural networks, ketamine helps patients break free from negative thought patterns and behavioral cycles, fostering a more positive and resilient outlook on life.


The intersection of psychedelic medicines, neuroplasticity, and the updating of internal working models opens a new frontier in the field of mental health. As our understanding of the brain's plastic nature deepens, researchers and therapists are exploring innovative ways to harness the therapeutic potential of these substances. While further studies are needed to fully elucidate the mechanisms at play, the current evidence suggests that psychedelic medicines, like ketamine, have the capacity to ignite profound transformations in our cognition, emotions, and behavior, ultimately leading to enhanced well-being and personal growth.

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